The Urology Research Laboratory at the University of Kentucky focuses on providing an environment for training the new generation of basic scientists and physician-scientists (graduate students, Medical students, post-doctoral fellows, residents and junior faculty) in translational research in urology. Programmatically our research efforts pursue (a) development of novel molecular therapeutics targeting the cytoskeleton and the tumor microenvironment to impair metastatic prostate, bladder and renal cancer; (Tumor invasion and metastasis is mediated by cell-matrix interactions to form adhesion complexes and actin polymerization drives the formation of cell protrusions and focal adhesions, directing cell migration); (b) identification of mechanisms of therapeutic cross-resistance to taxanes and anti-androgens in advanced castration-resistant prostate cancer; (understanding the role of the androgen receptor, AR in primary and acquired resistance to abiraterone and enzalutamide as well as to microtubule-targeting taxane chemotherapy, Cabazitaxel and Docetaxel, the androgen receptor, AR, and (c) profiling the landscape of epithelial-mesenchymal transition (EMT) and apoptosis kinetics towards identification of molecular signatures and their validation as biomarkers for prostate and bladder cancer progression. (using in vivo transgenic mouse models of tumor progression to study the contribution of EMT to invasive mesenchymal phenotype of cancer cells during progression to metastasis as well as therapeutic resistance).



Natasha Kyprianou, MD
(859) 323-9812